CXCL8 and glioblastoma: Their polarization is driven by various factors, including osteopontin from mesenchymal-like endothelial cells [35], glioblastoma stem cell (GSC)-derived signals (e.g., exosomal miR-200c-3p and CXCL8) [36], lactate, and CCL2/CD84–SHP2 signaling [37].