Furthermore, single-cell analysis of public datasets GSE152583 [35] and GSE221789 [33] (the aortas of the AAA mouse model) confirmed that a substantially higher DKK3 expression was found in VSMCs than in ECs, macrophages, and other inflammatory cells, and the expression was increased along with the AAA progression (Fig. 1G). This evidence concerns the gene DKK3 and triple-A syndrome.