Furthermore, in db/db mice, the hyperglycemic environment of diabetes stimulates microglia to produce reactive oxygen species and activates the NF-κB/NLRP3 signaling pathway, leading to the production of NLRP3 inflammasome (e.g., IL1β, IL6, and IL18), which in turn mediates cognitive dysfunction (27). The gene discussed is NFKB1; the disease is diabetes mellitus.