GRIN2A and Alzheimer disease: In old mice, GluN2A levels were significantly higher in WT compared to AD mice in the hippocampus (ANOVA, p = 0.03, F (1,12) = 4.92) and cortex (ANOVA, p = 0.007, F (1,12) = 9.50), with no significant differences observed in other regions (Figures 2A,2B).