In contrast, GluN2B subunit expression showed significant decrease with aging in WT and AD mice region-wide (hippo: ANOVA, p < 0.001, F (1, 12) = 25.7; pfc: ANOVA, p < 0.001, F (1, 12) = 23.1; ctx: ANOVA, p = 0.008, F (1, 12) = 21.81; mb: ANOVA, p < 0.001, F (1, 12) = 27.2, n ≥ 4; Figures 2C,D). The gene discussed is GRIN2B; the disease is Alzheimer disease.