We investigated the expression dynamics of GluN2A- and GluN2B-NMDAR subunits in Tg2576 and wild-type (WT) mice in the cortex, prefrontal cortex, hippocampus, and midbrain, regions associated with plasticity and implicated in AD progression, using immunoblotting (Figure color code: blue-excitatory, red-inhibitory). Here, GRIN2B is linked to Alzheimer disease.