Agonists linked to peptide antigens in self-assembling nanoparticle vaccines (SNP-7/8a) enhanced CD8+ T cell immunity against tumor neoantigens, improved antigen uptake by DCs, and enhanced CD8+ T cell primingSNP-7/8a peptides directly stimulated CD8+ T cells, synergizing with TCR activation to increase expression of activation markers and cytokine production in a MyD88-dependent mannerMTAs of TLR7/8 agonists enhanced CD8+ T cell mediated antitumor responses. The gene discussed is MYD88; the disease is neoplasm.