NKG2D supports memory differentiation in CD8+ T cellsNKG2D/Dap10 weakly activates mTORC1 signaling leading to upregulation of memory genes, Sell and Il7rEnhances IL-15-mediated PI3K activity to reinforce CD8+ T cell memory differentiationNKG2D-deficient CD8+ T cells exhibit impaired survival and persistence, and blockade interferes with memory developmentTCF1 can regulate NKG2D expression on tumor-specific CD8+ T cells. Here, IL15 is linked to neoplasm.