RIG-I acts as a checkpoint molecule in tumor-specific T cellsKnockdown of RIG-I increased anti-apoptotic proteins (Bcl-2/Bcl-xL) and reduces caspase-3 mediated apoptosisRIG-I is a negative regulator of Akt, altering T cell metabolismRIG-I can sequester HSP90 and thus restrain STAT5 activation, inhibiting T cell cytotoxicity. The gene discussed is CASP3; the disease is neoplasm.