EDARADD and neoplasm: EDARADD, a transcriptional co-regulator associated with EGFR signaling pathways, appears to orchestrate multiple metastatic processes including epithelial-mesenchymal transition (EMT), tumor proliferation, invasion, angiogenesis, extravasation, and T-cell suppression through EGFR activation, cytokine production, and extracellular matrix modulation (81–83).