Under the influence of TGF-β, IL-8, IL-6, and IL-17, neutrophils polarize into the N2 subtype, characterized by prolonged lifespan, an immature phenotype, reduced cytotoxicity, and pro-tumor functions, including promotion of tumor growth, invasion, metastasis, angiogenesis, and immune suppression (73). The gene discussed is TGFB1; the disease is neoplasm.