While no studies have directly linked the S100A8/A9 protein to cardiac arrhythmia onset or maintenance, its established effects on the triad inflammation, calcium handling, and mitochondrial function, all of which are interconnected in arrhythmogenesis, suggest that S100A8/A9 may play an indirect role in cardiac arrhythmogenicity. This evidence concerns the gene S100A8 and cardiac arrhythmia.