S100A8 and Sepsis: S100A8/A9 binding to RAGE receptors on cardiomyocytes in sepsis might lead to cardiomyocyte dysfunction observed in experimental studies due to a decrease in cardiomyocyte contractility, possibly through their interaction with the calcium-regulating proteins SERCA2 and/or RyR2, thereby altering intracellular Ca2+ handling (70).