Consequently, researchers have developed an advanced DNA nanodevice incorporating an ATP-responsive aptamer sensor and an matrix metalloproteinase 2/9 (MMP2/9)-cleavable peptide-nucleic acid copolymer, which is engineered to sequentially interact with metastasis-related targets, MMP2/9 and ATP, within the extracellular tumor microenvironment, thereby enabling the concurrent detection of multiple biomarkers that promote tumor metastasis (111). The gene discussed is MMP2; the disease is neoplasm.