PTK7 and acute lymphoblastic leukemia: To address this, the researchers engineered a nucleic acid AND logic gate sensor utilizing dual aptamers to enable the concurrent detection of two tumor-associated proteins: protein tyrosine kinase 7 (PTK7) and prostate-specific membrane antigen (PSMA) in exocrine T lymphocytes from human acute lymphoblastic leukemia, which enhances the detection accuracy and holds potential for application in tumor diagnosis (113).