MTOR and obesity due to melanocortin 4 receptor deficiency: This review links metabolic stress (overnutrition) directly to enhanced mTOR signaling in cardiovascular tissues. It highlights that mTOR promotes a pro-inflammatory M1 macrophage polarization and modulates T-cell differentiation (Th1, Th17, Treg), which is central to the maladaptive immune response in obesity-related CVD. It also mentions mTOR’s link to the sympathetic nervous system. This provides a strong bridge between CMVD risk factors and mTOR-driven vascular inflammation.