MDH1 and colon adenocarcinoma: Conversely, MDH1 mRNA expression was found to be reduced in breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), glioblastoma multiforme (GBM), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), and thyroid carcinoma (THCA), as illustrated in Figure 2C.