Our results identified significant upregulation of MDH1 mRNA in several cancers, such as cholangiocarcinoma (CHOL), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), hepatocellular carcinoma (LIHC), head and neck squamous cell carcinoma (HNSC), LUAD, lung squamous cell carcinoma (LUSC), uterine corpus endometrial carcinoma (UCEC) and stomach adenocarcinoma (STAD). The gene discussed is MDH1; the disease is head and neck squamous cell carcinoma.