Conversely, MDH1 mRNA expression was found to be reduced in breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), glioblastoma multiforme (GBM), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), and thyroid carcinoma (THCA), as illustrated in Figure 2C. The gene discussed is MDH1; the disease is invasive breast carcinoma.