The percentage of PD-L1+ EVs was also significantly increased in MM patients (89.63 ± 2.17%) versus HDs (75.68 ± 11.46%, p = 0.001), with comparably high levels in NDMM (94.73 ± 2.8%) and RRMM (95.7 ± 0.75%) (Figure 2H). This evidence concerns the gene CD274 and Miyoshi myopathy.