To elucidate the transcriptional changes and heterogeneity of malignant cells in EGFR/TP53 co-mutated NSCLC, we divided epithelial cells into six subgroups and tumor cell EGFR+ Epi into two subgroups (C1 and C2) by unsupervised clustering (Figures 2A,B). The gene discussed is TP53; the disease is neoplasm.