Six subpopulations of fibroblasts have been identified in EGFR/TP53 co-mutated NSCLC, of which three predominated in tumors: myofibroblastic CAFs (myCAFs: Fib_POSTN+), antigen−presenting CAFs (apCAFs: Fib_CD74+), and inflammatory CAFs (iCAFs: Fib_CXCR4+) (Figures 5A, B, Supplementary Figure S5A). Here, EGFR is linked to non-small cell lung carcinoma.