Through STAT3 activation, CD206+ M2 TAMs sustain a pro-tumor milieu, releasing VEGF, TGF-β, EGF, urokinase-type plasminogen activator (uPA), and multiple matrix metalloproteinases (MMPs), thereby promoting tumor growth, immune suppression, angiogenesis, metastasis, and chemoresistance (59). This evidence concerns the gene PLAU and neoplasm.