Relative gene expression analysis of synovial tissue showed that HGA reduced the expression profile of key pro-inflammatory cytokines in the RA synovium, including IL-6, TNF-α, IL-22, and IL-15, while markedly improving the transcriptional program of the key regulatory cytokine IL-10 (Figures 5A–E). The gene discussed is IL6; the disease is rheumatoid arthritis.