Key among these is HLA-Cw6, strongly associated with early-onset psoriasis within the PSORS1 region on chromosome 6p21, alongside other PSORS loci and genes regulating cytokine signaling, such as IL12B and IL23R, as well as NF-κB pathway components like TNFAIP3 and NFKBIA, which orchestrate inflammatory responses and epidermal proliferation (3, 16, 17). Here, NFKB1 is linked to psoriasis.