This family comprises three pro-inflammatory agonists (IL-36α, IL-36β, IL-36γ) and one receptor antagonist (IL-36Ra), which collectively play pivotal roles in inflammatory diseases such as psoriasis (notably generalized pustular psoriasis [GPP] and palmoplantar pustulosis [PPP]), atopic dermatitis, hidradenitis suppurativa, Netherton’s syndrome, inflammatory bowel disease, and idiopathic pulmonary fibrosis (103). This evidence concerns the gene IL36A and palmoplantar pustulosis.