Specifically, PKM2-induced CXCL1 and MIF produced by tumor cells can bind to CXCR2 and CXCR4 receptors on MDSCs, thereby activating the signaling pathway of MDSCs and triggering cytoskeletal rearrangement, which makes MDSCs chemotactic to the periphery of tumor cells. This evidence concerns the gene CXCR2 and neoplasm.