HLA-DRB1 and primary biliary cholangitis: Ten variants (A*3303, B*4403, DPB1*0201, DPB1*0501, DQB1*0301, DQB1*0401, DQB1*0601, DRB1*08, DRB1*0803, DRB1*1101) had associations with PBC risk at genome-wide significance level (P < 5.0×10-8), among which DQB1*0301, DRB1*08, DRB1*0803 and DRB1*1101 were previously identified genome-wide significant risk loci (Table 1).