Additionally, meta-analyses of candidate-gene association studies provided strong evidence supporting the association of eight further variants (A*3303, B*4403, DPB1*0201, DQB1*0401, rs231725, rs231775, rs1544410, and rs9303277) with PBC at the genome-wide significance level (P < 5.0 × 10-8). The gene discussed is HLA-DPB1; the disease is primary biliary cholangitis.