By driving both innate and adaptive immune responses, the NLRP3 inflammasome is linked to the pathogenesis of various autoimmune diseases, including type 1 diabetes, cystic fibrosis, rheumatoid arthritis, autoimmune colitis, psoriasis, systemic lupus erythematosus, and systemic sclerosis (4, 93). The gene discussed is NLRP3; the disease is autoimmune disease.