Mechanistically, reduced platelet miR-199b-3p in LAC likely derepresses KTN1, mirroring its established tumor-promoting functions: CRISPR/Cas9 studies confirm KTN1 knockout suppresses proliferation, inhibits migration/invasion, and dysregulates innate immune responses in HCC/TNBC models (62, 63). The gene discussed is KTN1; the disease is hepatocellular carcinoma.