EPB41L3 and cancer: There has been a growing body of evidence to reveal the roles of platelet miRNAs in various pathophysiological processes as well as cancer pathogenesis, such as platelet miR-34c-3p and miR-18a-5p as potential liquid biopsy biomarkers for nasopharyngeal carcinoma diagnosis and miRNA-223 delivered by platelet-derived micro vesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3 (25, 71).