TNF and Fabry disease: Common conditions such as obesity, type 2 diabetes, and hypertension also share a chronic, low-grade inflammatory profile, where persistent elevation of cytokines like IL-1β, IL-6, and TNF-α acts as a catalyst for endothelial dysfunction, vascular injury, and disease advancement.6,7 A similar pattern has been described in Fabry disease, with immune activation preceding visible organ damage.8, –10