PDIA3 and obstructive sleep apnea syndrome: At the same time, we will conduct cell and animal experiments to establish an OSA disease model, deeply explore the molecular regulatory pathways of HIF1A and PDIA3 in the occurrence and development of OSA, clarify their mechanisms of action through gene knockout and overexpression techniques, and integrate findings from a large clinical cohort to validate the efficacy of both as diagnostic markers, thereby providing a more solid basis for the diagnosis and treatment of OSA.