As a well-established autoantigen, TROVE2 is implicated in multiple autoimmune diseases, including Sjögren’s disease (SjD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SSc), where anti-TROVE2 autoantibodies are frequently detected. Here, RO60 is linked to rheumatoid arthritis.