RO60 and systemic lupus erythematosus: As a well-established autoantigen, TROVE2 is implicated in multiple autoimmune diseases, including Sjögren’s disease (SjD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SSc), where anti-TROVE2 autoantibodies are frequently detected.