After controlling for age, initial NIHSS score, diabetes mellitus, stroke subtype, WBC, neutrophils and FBG, the AIP (OR, 1.657; 95% CI 1.432–1.875, p < 0.001), NHHR (OR, 1.519; 95% CI 1.342–1.811, p < 0.001) and sICH (OR, 1.931; 95% CI 1.324–2.317, p = 0.002) were found to be independent predictors for post-thrombolysis END (Figure 3). The gene discussed is AIP; the disease is Stroke.