In this context, EZM0414, a clinical-grade SETD2 inhibitor, was being evaluated in a phase I clinical trial as a therapeutic in relapsed or refractory multiple myeloma and diffuse large B cell lymphoma, suggesting that at least in these cancer types, H3K36me3 generation may be oncogenic (NCT05121103; note this trial was terminated). Here, SETD2 is linked to plasma cell myeloma.