SPINT2 and breast carcinoma: We note significant upregulation of genes such as EFNA1, PTMA, SPINT2, and CD24, which have previously been indicated in increased tumor aggression and driving the transition to invasive forms of breast cancer.[45] Angiogenesis signaling and PI3K‐Akt signaling, captured in Figure 4e, are pathways which would promote cell mobility through alterations in cell adhesion or through the formation of new blood vessels, and therefore influence the development of invasive properties.[46] Apoptosis and G2‐M Checkpoint, meanwhile, affect the proper regulation of the cell cycle and programmed cell death.