Aberrations in pathways such as KRAS signaling up, Myc Targets I, and TNF‐Alpha signaling can create a tumor‐promoting environment and lead to tumorigenesis.[42, 43, 44] We may speculate that multiscale analysis based on transcription similarity paired with deep spatial learning encourages the formation of clusters that emerge along functional gradients to a greater extent than the single inclusion of spatial information would allow. Here, TNF is linked to neoplasm.