These observations were in line with previous evidence that altered Ca2+ handling gene and protein expression occurred in ARVC.[33, 34, 35, 36] Functionally, ARVC iPSC‐CMs exhibited a markedly enhanced RYR2‐mediated SR Ca2+ leak, elevated diastolic Ca2+, irregular Ca2+ transients and arrhythmias. Here, RYR2 is linked to Arrhythmogenic right ventricular dysplasia.