TMEM43 and heart failure: TMEM43‐S358L was originally reported as the disease‐causing mutation in 15 extended families in the island of Newfoundland in Canada, which was associated with high penetrance and high risk of SCD and heart failure, with poor R‐wave progression and frequent LV dilatation.[9, 31] Genetic mice models to study TMEM43‐S358L were recently generated, but their phenotypes were highly inconsistent.[6, 19, 32] So far, the molecular links between TMEM43 mutations and increased cardiac arrhythmogenesis remain largely elusive.