TMEM43 and arrhythmogenic right ventricular dysplasia 5: TMEM43 (encoded by the TMEM43 gene), first identified in 2001, is highly conserved across species and is present in mammalian heart.[5, 6] The function of TMEM43 is poorly understood, although it has been evidenced that TMEM43 is associated with linker of nucleoskeleton and cytoskeleton (LINC) complex components for physiological maintenance of the nuclear structure.[7, 8] Missense mutations in the TMEM43 gene cause ARVC type 5 (ARVC5).[9] However, the precise mechanisms linking the TMEM43 mutations to increased arrhythmogenesis are largely elusive.