Having determined that P386S is a pathogenic mutation that causes TMEM43‐related ARVC, we further identified potential signaling pathways closely associated with the arrhythmic phenotypes by performing genome‐wide RNA‐sequencing (RNA‐Seq) to compare the transcriptomes of ARVC iPSC‐CMs with their isogenic controls (Figure S6A, Supporting Information). Here, TMEM43 is linked to arrhythmogenic right ventricular cardiomyopathy.