DES and arrhythmogenic right ventricular cardiomyopathy: At least 16 genes associated with ARVC have been identified so far, encoding desmosome, adherens junction, cytoskeletal structure, ion transport, and cytokine proteins, respectively.[3, 4] Mutations in desmosomal genes were identified in approximately half of patients with ARVC.[1, 3, 4] Cytoskeletal structure proteins, including desmin, lamin A, transmembrane protein 43 (TMEM43), titin, and filamin C, constitute the second‐largest category of ARVC‐associated mutations.[4]