Secondly, to better understand the significance of a disrupted circadian clock, we investigated the impact of chronic jet‐lag conditions on prostate cancer growth using a hormone‐sensitive VCaP‐derived xenograft model of prostate cancer to provide insights into the complex interplay between circadian rhythmic disruption, circulating testosterone levels, and metabolic targets in the malignant growth of prostate cancer. Here, CLOCK is linked to prostate cancer.