Our previous multicohort study (including Chinese, American, and the Cancer Genome Atlas (TCGA) datasets) identified TWF2 as an independent prognostic biomarker in RCC, with elevated expression significantly correlated with reduced survival overall.[21] Therefore, elucidating the tissue‐specific molecular mechanisms and therapeutic potential of TWF2 in renal malignancies is of considerable importance. The gene discussed is TWF2; the disease is renal cell carcinoma.