Six genes, Collagen Triple Helix Repeat Containing 1 (CTHRC1), TWF2, Collagen Type VI Alpha 3 (COL6A3), Solute Carrier Family 38 Member 5 (SLC38A5), Interferon Induced Protein 44 (IFI44), and 2′‐5′ Olive Acid Synthetase Like (OASL), were identified as potential master regulators of RCC drug resistance and tumor development (Figure 1B–D; Figure S2A, Supporting Information). This evidence concerns the gene COL6A3 and renal cell carcinoma.