Dysregulation of Hippo signaling contributes to multiple pathologies, including malignancies and disorders of the eyes, heart, lungs, kidneys, liver, and immune system.[51, 52] RNA sequencing and functional characterization in RCC cells highlighted a central role for the Hippo pathway in TWF2‐mediated RCC progression and therapeutic resistance. This evidence concerns the gene TWF2 and renal cell carcinoma.