In osteosarcoma, COL6A3 promotes malignancy, whereas in bladder cancer, its downregulation suppresses proliferation, angiogenesis, and epithelial–mesenchymal‐transition‐associated metastasis, underscoring its context‐dependent function.[76, 77, 78, 79]SLC38A5 functions as an amino acid transporter and plays a critical role in cancer metabolism. The gene discussed is SLC38A5; the disease is osteosarcoma.