While 12/15-LOX inhibition has been proven to be protective in various models of ischemic and hemorrhagic stroke,25, , –28,31 5-LOX inhibition demonstrated beneficial effects in experimental TBI.29,32,33 To date, no studies have investigated the interaction of antiplatelet pre-medication and a possible beneficial effect of 12/15-LOX inhibition. The gene discussed is LOX; the disease is hemorrhagic stroke.