MAP3K6 and inborn mitochondrial metabolism disorder: By contrast, the patients with monogenic stroke conditions (Fabry disease and MAP3K6-related disease) had “faint” to “moderate” calcifications in individual locations, and lower TCS (4 and 14), whereas the patients with mitochondrial disease had calcifications ranging from “faint” to “severe and confluent” in individual locations and a mean TCS of 11.5.