DES and Desminopathy: Extending our previous work on W2711X filamin‐C knock‐in mice [16, 17], we here demonstrate the presence of xin actin‐binding repeat‐containing proteins 1 and 2 (xirp 1 and xirp 2) and filamin‐C‐positive sarcomeric lesions in longitudinal sections of soleus muscles derived from mouse models for human desminopathies, comprising heterozygous and homozygous R349P [24] and R405W [25, 26] desmin knock‐in mice as well as desmin knock‐out mice [27, 28].