Notably, pathways such as the NOD-like receptor signaling pathway, PPAR signaling pathway, and chemokine signaling pathway were prominently enriched, suggesting that disc degeneration is associated with innate immune recognition, lipid-mediated transcriptional regulation, and inflammatory cell recruitment—hallmarks of an enhanced local innate immune response in degenerated NP tissue (Figure 2e). This evidence concerns the gene PPARA and intervertebral disk degenerative disorder.