NPFFR2 and obesity due to melanocortin 4 receptor deficiency: This study aimed to investigate the systemic role of NPFFR2 in obesity-induced metabolic dysfunction.<h4>Material and methods</h4>The role of NPFFR2 was examined using wild-type and Npffr2-overexpressing transgenic mice subjected to 15 weeks of high-fat high-sucrose diet to induce obesity.