TRPM7 and colorectal cancer: Additionally, we hypothesize that C. maltaromaticum mediates the effect of Mg treatment on circulating levels of vitamin D. We test these hypotheses within the Personalized Prevention of Colorectal Cancer Trial (PPCCT), a double-blind, precision-based randomized controlled trial (RCT) which was designed to test the interaction between Mg treatment and TRPM7 genotype on gut carcinogenic biomarkers [14,15].