Other examples include Derlin-2 being implicated in aiding chemotherapy resistance through increasing the half-life of procancer protein BAG6 (49), RHBDD2 being shown to be upregulated in breast cancer (48), and RHBDF2 (otherwise known as iRhom2) being shown to directly affect keratin (K16) levels, which can lead to cancer (50). Here, RHBDF2 is linked to breast carcinoma.