SLC1A2 and Alzheimer disease: Memantine is a relatively safe drug with few side effects, but it exerts inadequate clinical effects on cognition, global functioning, and activities of daily living.[67] In neurodegenerative disorders, an insufficient level of GLT‐1 is considered to be the leading cause of excitotoxicity.[68] Clinical studies and experimental models have shown that a loss of GLT‐1 is involved in the pathological features of AD.[68, 69] Accordingly, restoring GLT‐1 protein expression and function may reduce excitotoxicity and provide therapeutic benefits in AD.