We identified a number of novel genes related to lapatinib-acquired drug resistance, including CSF3R, TLE6, GABRE and PAD12. Additionally, the low expression of RAP1GAP, a tumour suppressor gene, whose low expression levels are associated with epithelial-mesenchymal transition (EMT), a phenotype of aggressive cancers [20]. The gene discussed is RAP1GAP; the disease is neoplasm.