The aggressive nature of lapatinib-resistant cells is evident compared to their cancer counterpart, as our analysis shows significant anchorage-independent growth (Fig. 1d), which correlates with hyperactivation of the MAPK and KRAS pathways (Figs. 2f and 4e), leading to an enhanced transformational potential (Fig. 1d, e) [43]. This evidence concerns the gene KRAS and cancer.