BATF2 and colorectal cancer: Specifically, indirect regulation of cyclin D1 by BATF2 has been characterized in colorectal cancer, in which sequestration of BATF2 in the cytosol via interaction with the nuclear export sequence of chromosome region maintenance 1 contributes to increased cellular proliferation through heightened activation of the AP-1–cyclin D1–phosphoretinoblastoma signaling axis (37).