On the other side, the co-expressed, secretable EGFRxCD3 moiety may induce further killing of EGFR+ tumor cells in situ, mediated by both the gene-modified CIK cells themselves, but also by non-modified CIK cells, since these will be activated by the anti-CD3 moiety of the sBiTE, as already reported in similar settings [47]. Here, EGFR is linked to neoplasm.