Another finding was the upregulation of IL−4R in CD8 T cells from responders, which is noteworthy since a recent study highlighted that anti-PD-1 preferably binds to follicular helper T cells which triggers the release of IL-4 that in turn boosts CD8 T cell responses in the draining lymph node and tumor immunity (Fig. 3B). Here, IL4R is linked to neoplasm.