CD8A and neoplasm: In support of our findings, Thommen et al. have found that the CD8+PD-1+ T cells subset was found to be tumor reactive and via TcR sequencing found to represent a high clonality, with top 30 clones comprising of almost 90% of the TcR repertoire which indicated that a majority of CD8+PD-1+ T cell clones were tumor specific [29].