KCNT1 and epilepsy: Clinically, there have been case reports of patients with KCNT1 epilepsy whose seizures have been reduced with the antitussive drugs tipepidine and dextromethorphan,21 the former of which has since been found to inhibit KCNT1 channels,20 and by fluoxetine, which, in addition to several other ion channels, has now been found to inhibit KCNT1.22, 23