While VEGF‐A is a principal driver of angiogenesis in ALL, other molecules such as basic fibroblast growth factor (bFGF), platelet‐derived growth factor (PDGF), and cytokines including IL‐6 and IL‐8 also contribute to remodeling the tumor microenvironment and supporting leukemic cell survival [32]. This evidence concerns the gene FGF2 and acute lymphoblastic leukemia.