Basophil Notch signals have been demonstrated to contribute to the expulsion of HD Tm [38, 125], and one study has suggested that basophils, in addition to being promoted by TSLP, act as APCs during HD Tm infection to promote expulsion [39], although no trafficking of basophils to lymph nodes was observed during HD Tm infection, and the mechanisms underpinning basophil presentation of antigen during type two immunity, independent of DCs, have been disputed [126, 127, 128]. This evidence concerns the gene TSLP and Huntington disease.