TGFB1 and glomerulosclerosis: For example, butyrate has been shown to reduce glomerulosclerosis in mice with Adriamycin (ADR)-induced nephropathy by decreasing levels of proteoglycans, collagen deposition, and the expression of fibrotic markers, including TGF-β and collagen 4α1 (COL4α1), compared with untreated animals [11].