The improved biochemical measures of PCOS included androgen levels, lipids, HOMA-IR, blood glucose, insulin, LH/FSH ratio, DHEAS, SHBG, AFC, and AMH, while the improved symptoms of PCOS were irregular menstruation, infertility, OHSS, and weight gain [7,14,15,16,17,18,19,20]. The gene discussed is SHBG; the disease is Infertility.