In a human neuroblastoma SH-SY5Y cell line overexpressing the A53T mutant α-synuclein, Jiang et al. [225] showed that curcumin restored autophagic activity by inhibiting the mechanistic target of rapamycin (mTOR)/ribosomal protein S6 kinase beta-1 (p70S6K) signaling pathway, reducing α-synuclein accumulation. The gene discussed is RPS6KB1; the disease is neuroblastoma.