Changes in cytokine levels were also demonstrated after a 6-week intervention with baked products made with ancient or modern wheats (the latter as control) in participants with moderate irritable bowel syndrome, with reductions in IL-4, IL-6, IL-17, IFN-γ, and MCP-1, but not IL-8, IL-10, IL-12, MIP-1β, TNF-α, or IP-10 [20]. This evidence concerns the gene CCL4 and irritable bowel syndrome.