CALR and Salla disease: Three key pathological events characterize SD: (i) an initial triggering phase influenced by genetic susceptibility, hormonal modulation, and environmental exposures; (ii) epithelial cell dysregulation within the salivary glands; and (iii) chronic inflammation marked by lymphocytic infiltration, B-cell hyperactivity, and the production of anti-SSA/Ro and anti-SSB/La autoantibodies.