For instance, Prevotella melaninogenica has been associated with pro-inflammatory responses through MHC, CD80, and IFN-γ induction [91], whereas Haemophilus parainfluenzae appears to be protective; i.e., its reduced salivary levels in SD contrast with murine data showing that glandular inoculation restored salivary function, reduced sialoadenitis, and suppressed IFN-γ–producing T cells, with epithelial exposure inhibiting human CD8+ T-cell activation [92]. Here, CD80 is linked to sialadenitis.