Additionally, as discussed in our previous article, (immuno-)histological assessments as well as investigations into signaling pathways like small mothers against decapentaplegic homolog (SMAD)-2 and -3, matrix-Gla protein (MGP), osteocalcin (OC), cytokine signaling will be needed to further supplement our understanding of overall MK-7 effects in T2DM [68]. This evidence concerns the gene MGP and type 2 diabetes mellitus.