It has also been shown to induce microsatellite instability through suppression of MSH6 [34], facilitate liver metastasis via the miR-5692a/IL-8 axis [35], and modulate the tumor microenvironment through the outer membrane vesicles (OMVs) that induce immunosuppressive M2 macrophage polarization [36]. This evidence concerns the gene CXCL8 and neoplasm.