IL18 and colorectal carcinoma: Among its most relevant virulence factors is the adhesin FadA, which binds to E-cadherin on CRC cells, activates the β-catenin pathway, and stimulates the expression of oncogenes such as Myc and Cyclin D1, as well as inducing a proinflammatory response through IL-6, IL-8, and IL-18 [30].